2020;53(8):e9886. Does hyaluronic acid make you retain water? They can help you determine the root cause of your weight gain and suggest an appropriate course of action. Small molecular weight hyaluronic acid is any size from 20 to 300 kDa and research is suggesting any size of hyaluronic acid above 50 kDa cannot cause your skin pro-ageing inflammation. . It's unknown, but plausible, that intentionally adding HA to the tumors may promote their growth. Hyaluronic Acid Suppositories UK, hyaluronic acid vaginal gel (Hyalofemme) is used to ease vaginal dryness Italy, hyaluronic acid 5 mg suppositories with vitamin A & E were found to be a safe and effective alternative to estrogen Primary End point: Visual Analogue Scale Secondary End points: itching, burning, dyspareunia, irritation 2021;11(10):1518. doi:10.3390/biom11101518, Maheu E, Rannou F, Reginster JY. Hyaluronic acid does not lead to weight gain directly, as it has no caloric value. It is also important to note that weight gain can be caused by many factors, including diet, lifestyle, and lack of exercise. Does hyaluronic acid have an anti-aging effect? Wounds. Hyaluronic acid is generally well-tolerated and plays a role within the cosmetic, nutraceutical, and food industries. For instance, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends IAHA for managing knee osteoarthritis as a second-line treatment in people who remain severely symptomatic despite using non-steroidal anti-inflammatory drugs (NSAIDs). doi:10.1186/s13643-016-0363-9, Gocmen G, Aktop S, Tzner B, Goker B, Yarat A. A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye. According to research, topical hyaluronic acid results in skin hydration of up to 96% when used as a lotion, serum, and cream. Best hyaluronic acid molecular weight for skincare When injected into the joint, HA may cause the following: A prospective, multicenter randomized controlled trial that looked at the effectiveness of 0.2% HA cream on the skin compared to a neutral cream in the treatment of people with chronic leg ulcers reported the following treatment-related side effects. Of course its a free world and no-one is committing a crime here. Ultra Low Molecular Weight (ULMW) HA = lesss than 6,000 Daltons (6 kDa) The hyaluronic you want to use should be between 80,000 to 1,000,000 daltons (80 - 1,000 kDa). (https://pubmed.ncbi.nlm.nih.gov/29772338/), (https://www.ewg.org/skindeep/ingredients/702887-HYALURONIC_ACID/#.W7DSX2gzZhE), (https://onlinelibrary.wiley.com/doi/10.1111/j.1742-481X.2012.01057.x). Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. I have been formulating hyaluronic acid serums, gels and creams for cosmetic applications since 2003 - at different concentrations and of different molecular weights, all the way from 800 Da to 2 Mda. Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities. Listed below are some examples. Hyaluronic acid is a useful substance for its hydrating and lubricating properties, but it is not a factor in weight gain. Ideally you should drink two litres of water a day. Its molecule forms a three-dimensional network that acts like a sponge that literally traps water around and inside its folds. Hyaluronic acids chain-like structure also means it can act like a scaffold structure, allowing tissues to grow. Home > Nutrition > Does Hyaluronic Acid Cause Weight Gain? 2 MDa, not the bad one (20 MDa) that gathers in tissues with water retention / cellulite, The body breaks this 2 MDa HA down to smaller fragments (< 2 MDa) via the digestion process and later reassembles it, as needed, 50 kDa - 2MDa hyaluronic acid acts as an anti-inflammatory and in fact, HA supplements have been proven beneficial for joint as well as skin problems. A study of 51 people aged 25 to 75 with laryngopharyngeal reflux (LPR) symptoms showed that HA combined with chondroitin sulfate significantly reduced LPR-related symptoms such as chronic cough and hoarseness when given with proton pump inhibitor (PPI) therapy. Its primary role is to convert blood sugar (glucose) into energy using oxygen. 2020;243:116441. doi:10.1016/j.carbpol.2020.116441, Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: molecular mechanisms and therapeutic trajectory. However, guidelines vary for using intra-articular (within the joint) HA injection for osteoarthritis. These independent certifying bodies ensure that the ingredients listed on a product label are correct and pure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777704/. The Journal of clinical and aesthetic dermatology. It can also be found in skin care products, dermal fillers and supplements. Additionally, the improvement due to HA injections was more prolonged, persisting after six months. It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Yes. Hyaluronic acid is now of the most important anti-ageing actives in face skin care creams and serums - and is also found in some body products. A few of the different ways (available over-the-counter) that you can take hyaluronic acid include: Hyaluronic acid is also available by prescription in the following forms: Remember, only trained and qualified medical professionals should give injections. Hyaluronic acid (HA) is a natural polymer, i.e. Always consult your doctor. Eur Rev Med Pharmacol Sci. In addition to the conditions listed above, some people use HA to support the following conditions, although theres a lack of data demonstrating HAs efficacy for some: No side effects were noted in a review of several safety studies of HA. Healthy nutrition and exercise are absolutely essential for both cellulite prevention and reduction and to make the most of your treatments and creams. What is hyaluronic acid? (https://pubmed.ncbi.nlm.nih.gov/33278954/). Hyaluronic acid is LIKELY SAFE when taken by mouth, applied to the skin, or given by injection and appropriately. Read More Many HA serums and gels contain about 0.1% HA, i.e. Weight gain can be caused by a variety of factors, including diet, physical activity, genetics, medical conditions, and hormonal changes. But this usually resolves within 48 to 72 hours. A hyaluronic acid-binding contact lens with enhanced water retention. Check with your doctor or nurse immediately if any of the following side effects occur: Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Over-the-counter hyaluronic acid serums and products applied on your skin (creams, lotions, etc.) Trials. BTW, there is NO cellulite removal or long-term skin tightening/lifting with one, two or even three sessions and there is neither 100% (nor permanent) cellulite removal/skin tightening/lifting, with ANY technique, including ours, so we never make such misleading claims. In the past I have had some acid reflux but not as severe as after taking this supplement. Hyaluronic acid belongs to a type of long, complicated chain-like molecules called polymers. Not surprisingly this quite often results in permanent damage (the latest such fad is microneedling radiofrequency). Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. doi:10.1186/s13063-021-05053-7, Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Hyaluronic acid is widely used as an ingredient in fillers that repair or conceal scars left behind by acne. This article will primarily focus on the oral supplement use of HA. Since HA has a thick and sticky consistency and retains moisture, it helps the knee joint move smoothly and moisturizes the skin. Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: Molecular mechanisms and therapeutic trajectory. 2019;33(5):1457-1468. doi:10.1002/ptr.6338. 2016;5(1). A similar 12-week double-blind, randomized, placebo-controlled study conducted in 41 Taiwanese people aged 30 to 65 revealed that taking a 120 milligram (mg) HA capsule by mouth for 12 weeks improved skin wrinkles compared to the placebo. A quick search of Amazon for hyaluronic acid turns up thousands of products, from liquid serums to pills to creams that make a variety of claims. That is why hyaluronic acid has become a popular ingredient in skin care products, as it is believed to help restore and maintain the skins youthful appearance. Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence. The sizes above 1,000,000 Dalton form a film on the skin, while the smaller ones penetrate in the deeper skin layers. Effects of hyaluronic acid on bleeding following third molar extraction. Examples of such foods are bone broth, organ meats and joint cartilage. (https://pubmed.ncbi.nlm.nih.gov/27799626/). Some products, like this powder, make claims about hyaluronic acid . Dosage: How Much Hyaluronic Acid Should I Take? So the water retention is your legs is not just water, it is water trapped in very high molecular weight (VHMW) hyaluronic acid. While pregnant do stay away from retinols which are anti aging. Combine peoples ignorance, extreme marketing hype and greedy skincare companies and what do you get? 2016;28(3):78-88., Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O. Hyaluronic acid is a natural polysaccharide touted for its use in osteoarthritis, skin wrinkles, and dry eyes. Nutrition Journal. For information purposes only: All content on this website is strictly for information purposes only. Hyaluronan plays an important lubricating, cushioning, hydrating, immune, antioxidant, wound healing and skin repair role. While there is no clear documentation of clinically significant drug interactions noted in the literature, it is essential to consult with your healthcare provider before starting an HA supplement. Its important to tell your healthcare provider about all medications that youre taking, including supplements, vitamins, etc. So in practice, if you dilute high molecular weight HA 1% in water you will get a quite thick liquid or thin gel. This disaccharide has a molecular weight of 401.1 Dalton (Da). Well, for one, hyaluronic acid has a "high molecular weight" in its natural state, making it too large to actually sink into the skin. Here are 7 scientifically backed benefits of taking hyaluronic acid. (https://pubmed.ncbi.nlm.nih.gov/30287361/). (3)(9), In the skin, hyaluronic acid works by attracting water molecules from the air and dermis (the middle layer of skin) and holding them in place. By ensuring the skin has plenty of HA in the summer it can stay hydrated and protected from sun damage. Its especially useful for reducing the appearance of wrinkles and age lines. 2019;73(6):38-49. doi:10.5604/01.3001.0013.5776, Ibraheem W, Jedaiba WH, Alnami AM, et al. If you have concerns about water retention or any other side effects of hyaluronic acid, it is best to speak with a healthcare provider. (3). Sometimes they use huge concentrations, which are unnecessary or even counterproductive. J Appl Oral Sci. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. The lower molecular weights can obviously absorb much less water. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. 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